Details

Autor(en) / Beteiligte

• Narikawa, Koichi
• Fujihara, Kazuo
• Misu, Tatsuro
• Feng, Juan
• Fujimori, Juichi
• Nakashima, Ichiro
• Miyazawa, Isabelle
• Saito, Hiroshi
• Sato, Shigeru
• Itoyama, Yasuto

Titel

CSF-chemokines in HTLV-I-associated myelopathy: CXCL10 up-regulation and therapeutic effect of interferon-α

Ist Teil von

• Journal of neuroimmunology, 2005-02, Vol.159 (1), p.177-182

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2005

Quelle

MEDLINE

Beschreibungen/Notizen

• We measured four chemokines in the cerebrospinal fluid (CSF) in human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) with ELISA. CXCL10/IP-10, a T cell type 1 (Th1)-associated chemokine, was significantly elevated in HAM/TSP compared with controls, and the values were even significantly higher in HAM/TSP than in multiple sclerosis (MS) in which CXCL10/IP-10 up-regulation was previously reported. Among Th2-associated chemokines, CCL17/TARC and CCL11/Eotaxin in HAM/TSP were not different from those in controls. As shown in MS, CCL2/MCP-1 was significantly lower in HAM/TSP than in control. Following interferon (IFN)-α therapy in HAM/TSP, CCL2/MCP-1 became significantly higher than that before therapy, which may reflect a Th2 induction, while CXCL10/IP-10 remained elevated.