Bioorganic & medicinal chemistry letters, 2006-12, Vol.16 (23), p.6073-6077
2006
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Details
- Autor(en) / Beteiligte
- Titel
- Genotoxic activity of halogenated phenylglycine derivatives
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2006-12, Vol.16 (23), p.6073-6077
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2006
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The discovery and synthesis of genotoxic (haloaryl)glycines is reported. The discovery of genotoxic amino acids derived from phenylglycine, and posessing halogen substituents, is described. The utility of hypervalent iodine reagents in the synthesis of this class of compounds is highlighted. The mechanism of action of the (haloaryl)glycines was studied in Saccharomyces cerevisiae.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2006.08.111Titel-ID: cdi_proquest_miscellaneous_19851878
- Format
- –
- Schlagworte
- Amino acids, Antineoplastic agents, Benzamidines - chemistry, Biological and medical sciences, Cancer, Cell Line, Tumor, Cell Survival - drug effects, Cytotoxic, DNA Damage, General aspects, Genotoxic, Glycine - analogs & derivatives, Glycine - chemical synthesis, Glycine - chemistry, Glycine - toxicity, Halogens - chemistry, Humans, Medical sciences, Molecular Structure, Nitrogen - chemistry, Oxygen - chemistry, Pharmacology. Drug treatments, Phenylglycine, Saccharomyces cerevisiae, Saccharomyces cerevisiae - drug effects, Saccharomyces cerevisiae - genetics, Stereoisomerism, Structure-Activity Relationship