Details

Autor(en) / Beteiligte

• ter Veld, Marcel G. R
• Schouten, Bastiaan
• Louisse, Jochem
• van Es, Daan S
• van der Saag, Paul T
• Rietjens, Ivonne M. C. M
• Murk, Albertinka J

Titel

Estrogenic Potency of Food-Packaging-Associated Plasticizers and Antioxidants As Detected in ERα and ERβ Reporter Gene Cell Lines

Ist Teil von

• Journal of agricultural and food chemistry, 2006-06, Vol.54 (12), p.4407-4416

Ort / Verlag

Washington, DC: American Chemical Society

Erscheinungsjahr

2006

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• This study presents the estrogenic potency of 21 food-packaging-associated compounds determined for the first time, using two transfected U2-OS (human osteoblasts devoid of endogenous estrogen receptors) estrogen receptor (ER) alpha and beta cell lines. Six plasticizers and three antioxidants were slightly estrogenic in the ERα cells. The model compounds bisphenol A and nonylphenol, one plasticizer [tris(2-ethylhexyl)trimellitate (TEHTM)], and two antioxidants (propyl gallate and butylated hydroxyanisole) were estrogenic in both ERα and ERβ cells. Compared to estradiol (E2), these compounds appeared to be relatively more estrogenic in the ERβ cells than in the ERα cells. Three sorbitol-based plasticizers activated neither ERα nor ERβ and may be good replacements of existing plasticizers. All responses were additive with the response of E2. This indicates that they may contribute to the total effects of the pool of estrogenic compounds humans are exposed to. The estrogenic potencies of these compounds, together with the suggested beneficial effect of ERβ-mediated responses and adverse ERα-mediated effects, support the importance of detecting characteristics for ERα and ERβ response separately in independent models, as done in the present study. Keywords: Antioxidant; endocrine disrupter; ERα; ERβ; estrogen; food packaging; plasticizer; pseudo-estrogen