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Synthesis of Difluoromethylthioesters from Aldehydes
Ist Teil von
Angewandte Chemie (International ed.), 2018-02, Vol.57 (6), p.1663-1667
Auflage
International ed. in English
Ort / Verlag
Germany: Wiley Subscription Services, Inc
Erscheinungsjahr
2018
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Difluoromethylthioester compounds are yet another important kind of organofluorine compound and are reported here for the first time. They can be efficiently synthesized from various aldehydes. The synthetic method features mild reaction conditions, good tolerance of functional groups, broad substrate scope, and importantly, no metal is involved in the reaction. The approach has the potential to become an important tool for the late‐stage functionalization of advanced synthetic intermediates, and should have many applications in medicinal chemistry.
Difluoromethylthioester compounds have been efficiently synthesized from aldehydes for the first time. The synthetic method features mild reaction conditions, good tolerance of functional groups, and broad substrate scope, including (hetero)aromatic aldehydes, aliphatic aldehydes, and α,β‐unsaturated aldehydes.