Details

Autor(en) / Beteiligte

• Lu, Changhui
• Lu, Hao
• Wu, Jiang
• Shen, Hong C
• Hu, Taishan
• Gu, Yucheng
• Shen, Qilong

Titel

Palladium-Catalyzed Difluoromethylation of Aryl Chlorides and Triflates and Its Applications in the Preparation of Difluoromethylated Derivatives of Drug/Agrochemical Molecules

Ist Teil von

• Journal of organic chemistry, 2018-01, Vol.83 (2), p.1077-1083

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A palladium-catalyzed difluoromethylation of a series of aryl chlorides and triflates under mild conditions was described. A variety of common functional groups were tolerated. In addition, by using this protocol, several drug molecules containing an aryl chloride unit were successfully difluoromethylated, thus enabling medicinal chemists to rapidly access novel drug derivatives with potentially improved properties via late-stage functionalization.