Details

Autor(en) / Beteiligte

• Cui, Wen
• Wang, Jin
• Nie, Rui‐Min
• Zhao, Ling‐Ling
• Gao, Meng‐Qing
• Zhu, Hong‐Ming
• Chen, Li
• Hu, Jiong
• Li, Jun‐Min
• Shen, Zhi‐Xiang
• Wang, Zhen‐Yi
• Chen, Sai‐Juan
• Chen, Zhu
• Wang, Kan‐Kan
• Xi, Xiao‐Dong
• Mi, Jian‐Qing

Titel

Arsenic trioxide at conventional dosage does not aggravate hemorrhage in the first‐line treatment of adult acute promyelocytic leukemia

Ist Teil von

• European journal of haematology, 2018-04, Vol.100 (4), p.344-350

Ort / Verlag

England: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Quelle

Wiley Online Library

Beschreibungen/Notizen

• Objectives The arsenic trioxide (ATO) plus all‐trans retinoic acid (ATRA) therapy has demonstrated a tremendous success in the first‐line treatment of acute promyelocytic leukemia (APL). Actually, early death (ED) is currently thought as a major challenge in APL. ATO has been reported to inhibit platelet function in vitro, and whether it increases the ED rate by exacerbating the hemorrhagic symptoms remains to be investigated. Methods Effects of ATO on platelet aggregation and adhesion were evaluated in vitro and in thirty‐two complete remission (CR) and four newly diagnosed APL patients. Furthermore, concentrations of plasma total arsenic were monitored in APL patients via ICP‐MS. Results The inhibition of platelet function, either aggregation or adhesion, did occur in vitro when the concentration of ATO reached 2 μmol/L. However, in CR APL patients receiving ATO with normal platelet count, the platelets responded normally when being activated and so did those in the newly diagnosed patients with thrombocytopenia. Our data further showed that the conventional dosage of ATO reached a plasma concentration substantially below the required concentration to inhibit platelets. Conclusions In the first‐line treatment of APL, the use of ATO is safe and effective and does not compromise the hemostatic potential that may eventually increase ED rate.