Details

Autor(en) / Beteiligte

• Poh, Si Bei
• Ong, Jun‐Yang
• Lu, Shenci
• Zhao, Yu

Titel

Highly Regio‐ and Stereodivergent Access to 1,2‐Amino Alcohols or 1,4‐Fluoro Alcohols by NHC‐Catalyzed Ring Opening of Epoxy enals

Ist Teil von

• Angewandte Chemie International Edition, 2018-02, Vol.57 (6), p.1645-1649

Auflage

International ed. in English

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Described is an unprecedented NHC‐catalyzed (NHC=N‐heterocyclic carbene), stereoselective ring opening of epoxy and cyclopropyl enals to deliver valuable compounds bearing multiple stereocenters. A straightforward three‐step procedure involving two catalytic enantioselective transformations has been developed and leads to a regio‐ and stereodivergent synthesis of either 1,2‐amino alcohols/diamines or 1,4‐fluoro alcohols with excellent diastereo‐ and enantiopurity. Break wide open: An unprecedented NHC‐catalyzed (NHC=N‐heterocyclic carbene), stereoselective ring opening of epoxy and cyclopropyl enals delivers valuable compounds bearing multiple stereocenters. A straightforward three‐step procedure has been developed and leads to a regio‐ and stereodivergent synthesis of either 1,2‐amino alcohols or 1,4‐fluoro alcohols with excellent diastereo‐ and enantiopurities.