Details

Autor(en) / Beteiligte

• Ramirez, Marcel I
• Amorim, Maria G
• Gadelha, Catarina
• Milic, Ivana
• Welsh, Joshua A
• Freitas, Vanessa M
• Nawaz, Muhammad
• Akbar, Naveed
• Couch, Yvonne
• Makin, Laura
• Cooke, Fiona
• Vettore, Andre L
• Batista, Patricia X
• Freezor, Roberta
• Pezuk, Julia A
• Rosa-Fernandes, Lívia
• Carreira, Ana Claudia O
• Devitt, Andrew
• Jacobs, Laura
• Silva, Israel T
• Coakley, Gillian
• Nunes, Diana N
• Carter, Dave
• Palmisano, Giuseppe
• Dias-Neto, Emmanuel

Titel

Technical challenges of working with extracellular vesicles

Ist Teil von

• Nanoscale, 2018-01, Vol.1 (3), p.881-96

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Extracellular Vesicles (EVs) are gaining interest as central players in liquid biopsies, with potential applications in diagnosis, prognosis and therapeutic guidance in most pathological conditions. These nanosized particles transmit signals determined by their protein, lipid, nucleic acid and sugar content, and the unique molecular pattern of EVs dictates the type of signal to be transmitted to recipient cells. However, their small sizes and the limited quantities that can usually be obtained from patient-derived samples pose a number of challenges to their isolation, study and characterization. These challenges and some possible options to overcome them are discussed in this review. Extracellular Vesicles (EVs) are gaining interest as central players in liquid biopsies, with potential applications in diagnosis, prognosis and therapeutic guidance in most pathological conditions.