Details

Autor(en) / Beteiligte

• Wang, Chengjun
• Zuo, Yuegang
• Vinson, Joe A.
• Deng, Yiwei

Titel

Absorption and excretion of cranberry-derived phenolics in humans

Ist Teil von

• Food chemistry, 2012-06, Vol.132 (3), p.1420-1428

Ort / Verlag

Kidlington: Elsevier Ltd

Erscheinungsjahr

2012

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• ► Sixteen cranberry-derived phenolic and aromatic acids have been identified and quantified in human fluids. ► The conjugated phenolics were dominant species in human plasma and urine. ► The dietary intake of cranberry led to a fast gastric absorption of low molecular weight phenolics. ► Cranberry-derived phenolics were rapidly filtrated by the kidneys and accumulated in urine. ► The GC–MS-SIM technique provides a sensitive determination of phenolics in biological fluids. Absorption and excretion of twenty cranberry-derived phenolics were studied following the consumption of cranberry juice, sauces, and fruits by healthy human volunteers. Plasma and urine samples were collected and analysed by gas chromatography–mass spectrometry (GC–MS). A high performance liquid chromatography (HPLC) method was employed for analysing urinary creatinine, which was used as a normalisation agent. Significant increases in the sum of plasma phenolics were observed with different concentration peaks (between 0.5 and 2h) for individual subjects. Some of the phenolics, such as trans-cinnamic, vanillic, p-coumaric acids, and catechin showed second plasma concentration peaks. All of cranberry-derived phenolics increased significantly in urine samples after the intake of each cranberry product. The high molecular weight quercetin and myricetin, which were abundant in cranberry foodstuffs, were not found in either plasma or urine samples. This study provided the fundamental information for understanding the absorption and excretion of phenolics in the human gastrointestinal system after dietary intake of cranberry products.