Details

Autor(en) / Beteiligte

• Ortiz, Mario I.
• Cariño‐Cortés, Raquel
• Ponce‐Monter, Héctor A.
• Castañeda‐Hernández, Gilberto
• Chávez‐Piña, Aracely Evangelina

Titel

Pharmacological interaction of α‐bisabolol and diclofenac on nociception, inflammation, and gastric integrity in rats

Ist Teil von

• Drug development research, 2018-02, Vol.79 (1), p.29-37

Ort / Verlag

United States

Erscheinungsjahr

2018

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Preclinical Research & Development The combination of nonsteroidal anti‐inflammatory drugs (NSAIDs) with herbal products having analgesic and anti‐inflammatory effects may increase their beneficial effects and limit their side effects. In this study, the effects of an interaction between α‐bisabolol and the NSAID, diclofenac on nociception (formalin test), inflammation (paw inflammation produced by carrageenan) and gastric injury in rat was assessed. Diclofenac, α‐bisabolol, or diclofenac–α‐bisabolol combinations produced antinociceptive and anti‐inflammatory effects in rat (p < .05). The systemic administration of diclofenac, but not α‐bisabolol, produced gastric damage while the diclofenac–α‐bisabolol combinations produced limited gastric damage. Effective dose (ED40) values were determined for each individual drug and analyzed isobolographically. The theoretical ED40 values for the antinociceptive (98.89 mg/kg) and the anti‐inflammatory (41.2 mg/kg) effects differed from the experimental ED40 values (antinociception: 38.7 mg/kg and anti‐inflammation: 13.4 mg/kg). We concluded that the interactions between diclofenac and α‐bisabolol are synergistic. These data suggest that the diclofenac–α‐bisabolol combinations can interact to produce minor gastric damage, thereby offering a safer therapeutic alternative for the clinical management of inflammation and/or inflammatory pain.