Details

Autor(en) / Beteiligte

• Liu, Q.
• Gao, L.‐L.
• Dai, Y.‐L.
• Li, Y.‐X.
• Wang, Y.
• Bai, C.‐F.
• Mu, G.‐X.
• Chai, X.‐M.
• Han, W.‐J.
• Zhou, L.‐J.
• Zhang, Y.‐J.
• Tang, L.
• Liu, J.
• Yu, J.‐Q.

Titel

Nitrous oxide/oxygen mixture for analgesia in adult cancer patients with breakthrough pain: A randomized, double‐blind controlled trial

Ist Teil von

• European journal of pain, 2018-03, Vol.22 (3), p.492-500

Ort / Verlag

England

Erscheinungsjahr

2018

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Background The aim of this study was to assess the efficacy of a fixed nitrous oxide/oxygen mixture for the management of breakthrough cancer pain. Methods/design A double‐blind, placebo‐controlled, randomized clinical trial was undertaken in the Medical ward of Tumor Hospital of General Hospital of Ningxia Medical University. 240 cancer patients with breakthrough pain were recruited and randomly received a standard pain treatment (morphine sulphate immediate release) plus a pre‐prepared nitrous oxide/oxygen mixture, or the standard pain treatment plus oxygen. The primary endpoint measure was the numerical rating scale (NRS) score measured at baseline, 5 and 15 min after the beginning of treatment, and at 5 min post treatment. Result In all, analysis of pain score (NRS) at 5 min after the beginning of treatment shown a significant decrease in nitrous oxide/oxygen mixture treated patients with 2.8 ± 1.3 versus 5.5 ± 1.2 in controls (p < 0.01). At 15 min during the intervention, the mean pain score for nitrous oxide/oxygen was 2.0 ± 1.1 compared with 5.6 ± 1.3 for oxygen (p < 0.01). Conclusion This study shows that self‐administered nitrous oxide/oxygen mixture was effective in reducing moderate to severe breakthrough pain among patients with cancer. Significance The management of breakthrough cancer pain is always a challenge due to its temporal characteristics of rapid onset, moderate to severe in intensity, short duration (median 30–60 min). Our study find that self‐administered nitrous oxide/oxygen mixture was effective in reducing moderate to severe breakthrough cancer pain.