Details

Autor(en) / Beteiligte

• Stern, Shay
• Kirst, Christoph
• Bargmann, Cornelia I.

Titel

Neuromodulatory Control of Long-Term Behavioral Patterns and Individuality across Development

Ist Teil von

• Cell, 2017-12, Vol.171 (7), p.1649-1662.e10

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Animals generate complex patterns of behavior across development that may be shared or unique to individuals. Here, we examine the contributions of developmental programs and individual variation to behavior by monitoring single Caenorhabditis elegans nematodes over their complete developmental trajectories and quantifying their behavior at high spatiotemporal resolution. These measurements reveal reproducible trajectories of spontaneous foraging behaviors that are stereotyped within and between developmental stages. Dopamine, serotonin, the neuropeptide receptor NPR-1, and the TGF-β peptide DAF-7 each have stage-specific effects on behavioral trajectories, implying the existence of a modular temporal program controlled by neuromodulators. In addition, a fraction of individuals within isogenic populations raised in controlled environments have consistent, non-genetic behavioral biases that persist across development. Several neuromodulatory systems increase or decrease the degree of non-genetic individuality to shape sustained patterns of behavior across the population. [Display omitted] •Long-term tracking reveals stereotyped behavioral trajectories in C. elegans•Spontaneous behavior is patterned within and between developmental stages•Some individuals have consistent, non-genetic behavioral biases•Neuromodulation regulates stage-specific behaviors and levels of individuality Individual nematodes exhibit consistent, non-genetic behavioral biases that are impacted by several neuromodulatory systems.