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The Long-term Effect of Different Combination Therapies on Glucose Metabolism in HIV/Aids Subjects in Cameroon
Ist Teil von
Journal of medical sciences (Faisalābād, Pakistan), 2007-05, Vol.7 (4), p.609-614
Erscheinungsjahr
2007
Link zum Volltext
Quelle
Free E-Journal (出版社公開部分のみ）
Beschreibungen/Notizen
The use of antiretroviral drugs is associated with an increase of metabolic abnormalities such as impaired glucose metabolism and insulin resistance. This study was designed to investigate the long-term effect of anti-retroviral combinations therapy on glucose metabolism in HIV/AIDS patients in Cameroon. A descriptive and prospective study was carried out on 58 patients on HAART and 80 pre-HAART patients. The various drugs regimens comprised Lamivudin-Zidovudin associated with Efavirenz (Therapy I, n = 9) or Nevirapin (Therapy II, n = 13) and Stavudin-Lamivudin associated with Nevirapin (Therapy III, n = 30) or Efavirenz (Therapy IV, n = 16). All patients were monitored at baseline and then 12 months after. Blood glucose levels increased significantly in both pre-HAART (34.08 plus or minus 9.93%) and HAART patients (45.56 plus or minus 7.86%) The mean blood glucose levels increasedby78.19%(p<0.001), 61.50%(p<0.0001), 69.96%(p<0.0001)and 16.92% (p<0.01) with therapy I, II, IV and III, respectively. The increase was associated with efavirenz or zidovudine use. It is possible that efavirenz or zidovudine use in a combination therapy may exaggerate an underlying tendency to develop mitochondrial toxicity or insulin resistance.