Details

Autor(en) / Beteiligte

• Bartov, M. S.
• Gromov, A. V.
• Manskih, V. N.
• Makarova, E. B.
• Rubshtein, A. P.
• Poponova, M. S.
• Savina, D. M.
• Savin, K. S.
• Nikitin, K. E.
• Grunina, T. M.
• Boksha, I. S.
• Orlova, P. A.
• Krivozubov, M. S.
• Subbotina, M. E.
• Lunin, V. G.
• Karyagina, A. S.
• Gintsburg, A. L.

Titel

Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) with Additional Protein Domain Synthesized in E. coli: In Vivo Osteoinductivity in Experimental Models on Small and Large Laboratory Animals

Ist Teil von

• Bulletin of experimental biology and medicine, 2017-12, Vol.164 (2), p.148-151

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2017

Quelle

Springer LINK 全文期刊数据库

Beschreibungen/Notizen

• Recombinant human bone morphogenetic protein-2 with an additional s-tag domain (s-tag-BMP-2) synthesized in E. coli is characterized by higher solubility and activity than the protein without additional s-tag domain, which increases the yield during purification and simplifies protein introduction into the osteoplastic materials. The high osteoinductivity of the demineralized bone matrix with s-tag-BMP-2 was shown on the model of regeneration of cranial defects of a critical size in mice and on the model of implantation of porous titanium matrix into defects of femoral and tibial bones in rabbits.