Details

Autor(en) / Beteiligte

• Wen, Lihui
• Shin, Min-Ho
• Kang, Ji-Hyoun
• Yim, Yi-Rang
• Kim, Ji-Eun
• Lee, Jeong-Won
• Lee, Kyung-Eun
• Park, Dong-Jin
• Kim, Tae-Jong
• Park, Yong-Wook
• Kweon, Sun-Seog
• Lee, Young-Hoon
• Yun, Yong-Woon
• Lee, Shin-Seok

Titel

The value of high-sensitivity C-reactive protein in hand and knee radiographic osteoarthritis: data from the Dong-gu Study

Ist Teil von

• Clinical rheumatology, 2018-04, Vol.37 (4), p.1099-1106

Ort / Verlag

London: Springer London

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Due to the inconsistent association between high-sensitivity C-reactive protein (hs-CRP) and osteoarthritis (OA), we evaluated the relationship between hs-CRP and various radiographic findings in older adults with OA. This cross-sectional study recruited 2376 participants from the population-based Dong-gu cohort. The scores of radiographic features in OA on X-rays of the knees and hands were computed using a semi-quantitative grading system. The hs-CRP levels were measured using a particle-enhanced immunonephelometry assay. Correlations showing the relationship between hs-CRP and OA were calculated using multiple linear correlation analysis. The hs-CRP levels were significantly higher in older subjects ( p  < 0.001), those with a higher body mass index (BMI) ( p  < 0.001), current smokers ( p  < 0.001), current alcohol drinkers ( p  = 0.011), those who were less physically active ( p  = 0.002), and those with a lower level of education ( p  = 0.043). After adjusting for BMI and other confounders, the total OA scores (knee, p  = 0.022; hand, p  = 0.029) and sclerosis score (knee, p  = 0.007; hand, p  = 0.030) in the knees and hands were all significantly positively correlated with hs-CRP. A significant association was also observed between hs-CRP and hand erosion score ( p  = 0.045), hand malalignment score ( p  = 0.015), and tibial attrition score ( p  = 0.039). In this large cross-sectional study, a higher hs-CRP level was significantly associated with radiographic OA severity. Of the various types of radiographic damage, all of sclerosis, erosion, and malalignment were significantly associated with hs-CRP levels.