Details

Autor(en) / Beteiligte

• Mignolet, Johann
• Panis, Gaël
• Viollier, Patrick H

Titel

More than a Tad: spatiotemporal control of Caulobacter pili

Ist Teil von

• Current opinion in microbiology, 2018-04, Vol.42, p.79-86

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• •The Caulobacter Tad/Cpa complex is regulated in space and time by trans-encoded factors.•Two parallel polarization pathways control the assembly of the polar secretion channel.•The transcripts of pilus assembly factors are regulated during the cell cycle.•Many trans-encoded piliation factors are also encoded in other α-proteobacterial genomes. The Type IV pilus (T4P) is a powerful and sophisticated bacterial nanomachine involved in numerous cellular processes, including adhesion, DNA uptake and motility. Aside from the well-described subtype T4aP of the Gram-negative genera, including Myxococcus, Pseudomonas and Neisseria, the Tad (tight adherence) pilus secretion system re-shuffles homologous parts from other secretion systems along with uncharacterized components into a new type of protein translocation apparatus. A representative of the Tad apparatus, the Caulobacter crescentus pilus assembly (Cpa) machine is built exclusively at the newborn cell pole once per cell cycle. Recent comprehensive genetic analyses unearthed a myriad of spatiotemporal determinants acting on the Tad/Cpa system, many of which are conserved in other α-proteobacteria, including obligate intracellular pathogens and symbionts.