Details

Autor(en) / Beteiligte

• Janssen, P. T. J.
• Breukink, S. O.
• Melenhorst, J.
• Stassen, L. P. S.
• Bouvy, N. D.
• Temel, Y.
• Jahanshahi, A.

Titel

Behavioral outcomes of a novel, pelvic nerve damage rat model of fecal incontinence

Ist Teil von

• Neurogastroenterology and motility, 2018-04, Vol.30 (4), p.e13242-n/a

Ort / Verlag

England: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Background Fecal incontinence (FI) has a multifactorial pathophysiology with a severe social impact. The most common cause for FI is pudendal nerve damage, which mostly occurs in women during or after labor. A better understanding of the pathophysiology is required to optimize treatment of FI. In this study, we evaluate the use of a novel pelvic nerve damage rat model of FI. Methods This new model simulates the forces on the pelvic floor during labor by prolonged transvaginal, retro‐uterine intrapelvic balloon distention in female rats. Number of fecal pellets produced per day and defecation pattern was compared between the experimental and control group for 2 weeks. The cages of the rats were divided in food, nesting and latrine areas to evaluate changes in defecation pattern. The FI Index (FII) was calculated to assess the ratio of fecal pellets between the non‐latrine areas and the total number of pellets. A higher score represents more random distribution of feces outside the latrine area. Results Total number of fecal pellets was higher in the experimental group as compared with the controls. In both groups most fecal pellets were deposited in the nesting area, which is closest to the food area. The experimental group deposited more fecal pellets in the latrine area and had a lower FII indicating less random distribution of feces outside the latrine area. Conclusion Transvaginal, retro‐uterine intrapelvic balloon distention is a safe and feasible animal model simulating the human physiologic impact of labor by downwards pressure on the pelvic floor. This study demonstrated that transvaginal, retro‐uterine, intrapelvic balloon distention is a safe and feasible animal model for induction of fecal incontinence simulating the human physiologic impact of labor.