Details

Autor(en) / Beteiligte

• Gao, P F
• Guo, X H
• Du, M
• Cao, G Q
• Yang, Q C
• Pu, Z D
• Wang, Z Y
• Zhang, Q
• Li, M
• Jin, Y S
• Wang, X J
• Liu, H
• Li, B G

Titel

LncRNA profiling of skeletal muscles in Large White pigs and Mashen pigs during development

Ist Teil von

• Journal of animal science, 2017-10, Vol.95 (10), p.4239-4250

Erscheinungsjahr

2017

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Long noncoding RNA (lncRNA) has been increasingly implicated in the regulation of muscle development. Large White pigs have a higher muscle growth rate than do Mashen pigs. In the present study, the lncRNA expression profiles in skeletal muscle of these 2 pig breeds were compared at 1, 90, and 180 d of age using RNA sequencing. We obtained 2,718 million clean reads and identified a total of 5,153 novel lncRNA. We found 1,407 differentially expressed lncRNA that showed consistent expression patterns between the 2 breeds at all the 3 sampling points. Ten lncRNA were randomly selected, and their expression was validated using Real-time Quantitative PCR. In summary, this study identifies a number of lncRNA that correlate with muscle growth. The regulation and function of these lncRNA in muscle growth and development need to be further explored.