Nucleosides, nucleotides & nucleic acids, 2007-01, Vol.26 (8-9), p.1001-1004
2007
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Details
- Autor(en) / Beteiligte
- Titel
- Asymmetric Synthesis of Novel Pseudo-d-Vinylcyclopropyl Nucleosides Bearing Quaternary Carbon as Potential Anti-Herpesvirus Agent
- Ist Teil von
- Nucleosides, nucleotides & nucleic acids, 2007-01, Vol.26 (8-9), p.1001-1004
- Ort / Verlag
- United States: Taylor & Francis Group
- Erscheinungsjahr
- 2007
- Quelle
- Taylor & Francis
- Beschreibungen/Notizen
- Pseudo-d-vinylcyclopropyl nucleosides 10-12 bearing a quaternary carbon were designed and synthesized starting from (R)-epichlorohydrin using a tandem reaction of double alkylation and lactonization via oxirane-ring opening reaction, a Wittig reaction, and chemoselective reduction as potential anti-herpesvirus agent.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1525-7770eISSN: 1532-2335DOI: 10.1080/15257770701508232Titel-ID: cdi_proquest_miscellaneous_19610644
- Format
- –
- Schlagworte
- Alkylation, anti-herpesvirus agent, Antiviral Agents - chemical synthesis, Antiviral Agents - chemistry, Antiviral Agents - pharmacology, double alkylation, Drug Design, Epichlorohydrin - chemistry, Herpesviridae - drug effects, Nucleosides - chemical synthesis, Nucleosides - chemistry, Nucleosides - pharmacology, oxirane-ring reaction, Pseudo-d-vinylcyclopropyl nucleosides, Stereoisomerism, Vinyl Compounds - chemical synthesis, Vinyl Compounds - chemistry