Microbes and infection, 2018-02, Vol.20 (2), p.89-100
2018
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- Autor(en) / Beteiligte
- Titel
- Iraqi propolis increases degradation of IL-1β and NLRC4 by autophagy following Pseudomonas aeruginosa infection
- Ist Teil von
- Microbes and infection, 2018-02, Vol.20 (2), p.89-100
- Ort / Verlag
- France: Elsevier Masson SAS
- Erscheinungsjahr
- 2018
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Autophagy is a cellular process for maintaining cellular homeostasis. This process can be induced by different factors, such as immune stimuli and pathogen-associated molecules. Autophagy has an important role in the control of IL-1β secretion by macrophages and other cell types. In present study, we describe a novel role for Iraqi propolis affecting autophagy in controlling the secretion of IL-1β in bone-marrow macrophages (BMDMs). After infection with Pseudomonas aeruginosa in the presence of propolis, the degradation of IL-1β was induced, and the activity of inflammasome was reduced. Iraqi propolis-induced autophagy in in vitro and in vivo models decreased the levels of IL-1β and caspase-1. Results indicated that IL-1β pathway production is regulated by autophagy via two different novel mechanisms, namely, regulation of the activation of NLRC4 inflammasome and IL-1β targeting for lysosomal degradation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1286-4579eISSN: 1769-714XDOI: 10.1016/j.micinf.2017.10.007Titel-ID: cdi_proquest_miscellaneous_1961040213
- Format
- –
- Schlagworte
- Animals, Apoptosis Regulatory Proteins - genetics, Apoptosis Regulatory Proteins - metabolism, Autophagosomes - drug effects, Autophagosomes - metabolism, Autophagy, Autophagy - drug effects, Calcium-Binding Proteins - genetics, Calcium-Binding Proteins - metabolism, Cell Line, Female, Gene Silencing, Humans, IL-1β, Inflammasome, Inflammasomes - drug effects, Inflammasomes - metabolism, Interleukin-1beta - blood, Interleukin-1beta - metabolism, Interleukin-1beta - secretion, Iraqi propolis, Macrophages - drug effects, Macrophages - metabolism, Macrophages - pathology, Mice, Mice, Inbred C57BL, NLRC4, Propolis - administration & dosage, Propolis - pharmacology, Pseudomonas aeruginosa, Pseudomonas aeruginosa - drug effects, Pseudomonas aeruginosa - physiology, Pseudomonas Infections - metabolism, Pseudomonas Infections - pathology