Biological and Pharmaceutical Bulletin, 2017/11/01, Vol.40(11), pp.1846-1855
2017
Details
- Autor(en) / Beteiligte
- Titel
- Germinated Waxy Black Rice Ameliorates Hyperglycemia and Dyslipidemia in Streptozotocin-Induced Diabetic Rats
- Ist Teil von
- Biological and Pharmaceutical Bulletin, 2017/11/01, Vol.40(11), pp.1846-1855
- Ort / Verlag
- Japan: The Pharmaceutical Society of Japan
- Erscheinungsjahr
- 2017
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- This study aimed to examine the anti-diabetic effect of germinated waxy black rice (GWBR) using streptozotocin (STZ)-induced diabetic rats. In the diabetic rats, GWBR supplementation for 8 weeks reduced plasma blood glucose concentrations, improved glucose clearance and prevented diabetes-induced weight loss. Rats with STZ-induced diabetes who received GWBR supplementation exhibited decreased expression of sodium-dependent glucose transporter 1 (SGLT1) and glucose transporter (GLUT) 2 genes and proteins in the small intestine via decreases in hepatocyte nuclear factor (HNF)-1α, HNF-1β, and HNF-4α, transcriptional factors that are involved in the regulation of SGLT1 and GLUT2, compared with the rats with STZ-induced diabetes that did not receive GWBR supplements. GWBR supplementation also enhanced the expression of GLUT4 and the genes and proteins involved in GLUT4 translocation, such as insulin receptor (IR) and insulin receptor substrate 1 (IRS1), and increased the phosphorylation of phosphoinositide 3-kinase (PI3K) and protein kinase B (PKB, Akt) proteins in skeletal muscle. GWBR further increased glycogen synthase (GS) 1 by decreasing glycogen synthase kinase (GSK)-3β in skeletal muscle. Interestingly, GWBR recovered STZ-impaired pancreatic β-cells, resulting in increased insulin synthesis and secretion. In addition, GWBR reduced serum triglyceride, total cholesterol, low-density lipoprotein cholesterol, aspartate transferase and alanine transferase concentrations and increased high-density lipoprotein cholesterol concentrations. Taken together, these findings suggest that GWBR could be a candidate for improving the diabetic condition by regulating glucose uptake in the intestine and muscle and regulating the secretion of insulin from the pancreas.
- Sprache
- Englisch; Japanisch
- Identifikatoren
- ISSN: 0918-6158eISSN: 1347-5215DOI: 10.1248/bpb.b17-00239Titel-ID: cdi_proquest_miscellaneous_1959322328
- Format
- –
- Schlagworte
- 1-Phosphatidylinositol 3-kinase, AKT protein, Alanine, Animals, anti-diabete, Blood Glucose, Cholesterol, Diabetes, Diabetes mellitus, Diabetes Mellitus, Experimental - blood, Diabetes Mellitus, Experimental - chemically induced, Diabetes Mellitus, Experimental - diet therapy, Dyslipidemia, Dyslipidemias - blood, Dyslipidemias - diet therapy, germinated waxy black rice, Germination, Glucose, Glucose - metabolism, Glucose transporter, Glucose Transporter Type 4 - metabolism, glucose uptake, Glycogen, Glycogen synthase kinase 3, Hepatocyte Nuclear Factors - metabolism, Humans, Hyperglycemia, Hyperglycemia - blood, Hyperglycemia - diet therapy, Insulin, Insulin - metabolism, Insulin receptor substrate 1, Insulin Receptor Substrate Proteins - metabolism, Insulin Secretion, Insulin-Secreting Cells - enzymology, Insulin-Secreting Cells - metabolism, Intestine, Small - enzymology, Intestine, Small - metabolism, Kinases, Lipids - blood, Low density lipoprotein, Male, Metabolic disorders, Muscle, Skeletal - enzymology, Muscle, Skeletal - metabolism, Musculoskeletal system, Oryza - chemistry, Oryza - growth & development, Pancreas, Phosphorylation, Proteins, Rats, Rats, Sprague-Dawley, Receptor, Insulin - metabolism, Rodents, Secretion, Skeletal muscle, Small intestine, Sodium, Sodium-Glucose Transporter 1 - metabolism, Streptozocin, Streptozocin - toxicity, streptozotocin-induced diabetic rat, Supplements, Transcription factors, Translocation