Details

Autor(en) / Beteiligte

• Pyo, Jeung Hui
• Ha, Sang Yun
• Hong, Sung Noh
• Chang, Dong Kyung
• Son, Hee Jung
• Kim, Kyoung‐Mee
• Kim, Hyeseung
• Kim, Kyunga
• Kim, Jee Eun
• Choi, Yoon‐Ho
• Kim, Young‐Ho

Titel

Identification of risk factors for sessile and traditional serrated adenomas of the colon by using big data analysis

Ist Teil von

• Journal of gastroenterology and hepatology, 2018-05, Vol.33 (5), p.1039-1046

Ort / Verlag

Australia: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Quelle

Access via Wiley Online Library

Beschreibungen/Notizen

• Background and Aim Little is known about the risk factors associated with serrated polyps, because the early studies, which occurred before the new World Health Organization classification was introduced, included mixtures of serrated polyps. This study aimed to evaluate the risk factors associated with the presence of sessile serrated adenomas (SSAs) and traditional serrated adenomas (TSAs) using big data analytics. Methods Using a case–control design, we evaluated the risk factors associated with the presence of SSAs and TSAs. Subjects who underwent colonoscopies from 2002 to 2012 as part of the comprehensive health screening programs undertaken at the Samsung Medical Center, Korea, participated in this study. Results Of the 48 677 individuals who underwent colonoscopies, 183 (0.4%) had SSAs and 212 (0.4%) had TSAs. The multivariate analysis determined that being aged ≥ 50 years (odds ratio [OR] 1.91, 95% confidential interval [CI] 1.27–2.90, P = 0.002) and a history of colorectal cancer among first‐degree relatives (OR 3.14, 95% CI 1.57–6.27, P = 0.001) were significant risk factors associated with the presence of SSAs and that being aged ≥ 50 years (OR 2.61, 95% CI 1.79–3.80, P < 0.001), obesity (OR 1.63, 95% CI 1.12–2.36, P = 0.010), and a higher triglyceride level (OR 1.63, 95% CI 1.12–2.36, P = 0.010) were independent risk factors associated with the presence of TSAs. Conclusions We used big data analytics to determine the risk factors associated with the presence of specific polyp subgroups, and individuals who have these risk factors should be carefully scrutinized for the presence of SSAs or TSAs during screening colonoscopies.