Nature genetics, 2017-12, Vol.49 (12), p.1714-1721
- Jasinska, Anna J
- Zelaya, Ivette
- Service, Susan K
- Peterson, Christine B
- Cantor, Rita M
- Choi, Oi-Wa
- DeYoung, Joseph
- Eskin, Eleazar
- Fairbanks, Lynn A
- Fears, Scott
- Furterer, Allison E
- Huang, Yu S
- Ramensky, Vasily
- Schmitt, Christopher A
- Svardal, Hannes
- Jorgensen, Matthew J
- Kaplan, Jay R
- Villar, Diego
- Aken, Bronwen L
- Flicek, Paul
- Nag, Rishi
- Wong, Emily S
- Blangero, John
- Dyer, Thomas D
- Bogomolov, Marina
- Benjamini, Yoav
- Weinstock, George M
- Dewar, Ken
- Sabatti, Chiara
- Wilson, Richard K
- Jentsch, J David
- Warren, Wesley
- Coppola, Giovanni
- Woods, Roger P
- Freimer, Nelson B
2017
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- Autor(en) / Beteiligte
- Jasinska, Anna J
- Zelaya, Ivette
- Service, Susan K
- Peterson, Christine B
- Cantor, Rita M
- Choi, Oi-Wa
- DeYoung, Joseph
- Eskin, Eleazar
- Fairbanks, Lynn A
- Fears, Scott
- Furterer, Allison E
- Huang, Yu S
- Ramensky, Vasily
- Schmitt, Christopher A
- Svardal, Hannes
- Jorgensen, Matthew J
- Kaplan, Jay R
- Villar, Diego
- Aken, Bronwen L
- Flicek, Paul
- Nag, Rishi
- Wong, Emily S
- Blangero, John
- Dyer, Thomas D
- Bogomolov, Marina
- Benjamini, Yoav
- Weinstock, George M
- Dewar, Ken
- Sabatti, Chiara
- Wilson, Richard K
- Jentsch, J David
- Warren, Wesley
- Coppola, Giovanni
- Woods, Roger P
- Freimer, Nelson B
- Titel
- Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate
- Ist Teil von
- Nature genetics, 2017-12, Vol.49 (12), p.1714-1721
- Ort / Verlag
- New York: Nature Publishing Group US
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Nelson Freimer and colleagues analyze gene expression data from multiple tissue samples combined with genotype data from vervet monkeys to catalog expression quantitative trait loci (eQTLs). They generate a transcriptome resource analogous to the GTEx project and perform comparative and eQTL enrichment analyses for various traits. By analyzing multitissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalog of expression quantitative trait loci (eQTLs) in a nonhuman primate model. This catalog contains more genome-wide significant eQTLs per sample than comparable human resources and identifies sex- and age-related expression patterns. Findings include a master regulatory locus that likely has a role in immune function and a locus regulating hippocampal long noncoding RNAs (lncRNAs), whose expression correlates with hippocampal volume. This resource will facilitate genetic investigation of quantitative traits, including brain and behavioral phenotypes relevant to neuropsychiatric disorders.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1061-4036, 1546-1718eISSN: 1546-1718DOI: 10.1038/ng.3959Titel-ID: cdi_proquest_miscellaneous_1957767695
- Format
- –
- Schlagworte
- 38, 38/39, 38/43, 38/91, 45, 631/208/199, 631/208/205/2138, Age, Agriculture, Animal Genetics and Genomics, Animal models, Animals, Behavior, Bioinformatics, Biomedical and Life Sciences, Biomedicine, Brain, Brain - growth & development, Brain - metabolism, Brain research, Cancer Research, Chlorocebus aethiops, Chlorocebus aethiops - genetics, Chlorocebus aethiops - growth & development, Datasets, Developmental stages, Fibroblasts, Gender differences, Gene expression, Gene Expression Profiling, Gene Function, Genetic diversity, Genetic Variation, Genome-Wide Association Study, Genomes, Genotype, Hippocampus, Human Genetics, Human resources, Humans, Immune response, Mental disorders, Pedigree, Phenotype, Pituitary gland, Polymorphism, Single Nucleotide, Quantitative trait loci, Quantitative Trait Loci - genetics, Tissues