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Morphological Characterization of the Myenteric Plexus of the Ileum and Distal colon of Dogs Affected by Muscular Dystrophy
Anatomical record (Hoboken, N.J. : 2007), 2018-04, Vol.301 (4), p.673-685
SchÄfer, Bárbara Tavares
Silveira, Mariana Póvoa
Palombit, Kelly
Mendes, Cristina Eusébio
Watanabe, Ii Sei
Miglino, Maria Angélica
Castelucci, Patricia
2018
Details
Autor(en) / Beteiligte
SchÄfer, Bárbara Tavares
Silveira, Mariana Póvoa
Palombit, Kelly
Mendes, Cristina Eusébio
Watanabe, Ii Sei
Miglino, Maria Angélica
Castelucci, Patricia
Titel
Morphological Characterization of the Myenteric Plexus of the Ileum and Distal colon of Dogs Affected by Muscular Dystrophy
Ist Teil von
Anatomical record (Hoboken, N.J. : 2007), 2018-04, Vol.301 (4), p.673-685
Ort / Verlag
United States: Wiley Subscription Services, Inc
Erscheinungsjahr
2018
Link zum Volltext
Quelle
Wiley Blackwell Single Titles
Beschreibungen/Notizen
ABSTRACT Duchenne‐like muscular dystrophy (canine dystrophinopathy) is a hereditary degenerative disease characterized by muscle changes similar to those described for Duchenne muscular dystrophy (DMD) and by alterations in the smooth muscles of the gastrointestinal tract. Some authors have suggested that these abnormalities may be associated with intestinal motility. This study analyzed the nitrergic and cholinergic neurons and P2X7 receptor expression in the myenteric plexus of the ileum and distal colon of dogs with muscular dystrophy. Immunohistochemical techniques were used to detect nitric oxide synthase (NOS) and acetylcholine transferase (ChAT) expression and to label all HuC/D‐ and P2X7 receptor‐immunoreactive (IR) neurons. Transmission electron microscopy and basic histology were performed for further analysis. The results showed that nitrergic neurons exhibited a Dogiel type I morphology in the ileum and distal colon. The neuronal profile results showed that there were fewer NOS‐, ChAT‐, and HuC/D‐IR neurons in the ileum than in the distal colon in the dystrophic (DT) dogs. Additionally, there were more NOS‐, ChAT‐ and HuC/D‐IR neurons per ganglion in the distal colon than in the ileum. The P2X7 receptor‐expressing neurons colocalized with nitrergic and cholinergic neurons. Transmission and light microscopy revealed collagen between the muscle fibers, between the circular and longitudinal muscle layers and within the myenteric ganglia of dogs with muscular dystrophy. These findings provide a morphological description of the myenteric neurons in the ileum and distal colon of these DT dogs and may contribute to a better understanding of the gastrointestinal disorders found in patients with DMD. Anat Rec, 301:673–685, 2018. © 2017 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1932-8486
eISSN: 1932-8494
DOI: 10.1002/ar.23708
Titel-ID: cdi_proquest_miscellaneous_1955061257
Format
–
Schlagworte
Acetylcholine
,
Animals
,
Choline O-Acetyltransferase - metabolism
,
Collagen
,
Colon
,
Colon - metabolism
,
Colon - pathology
,
distal colon
,
Dog Diseases - metabolism
,
Dog Diseases - pathology
,
Dogs
,
Duchenne's muscular dystrophy
,
dystrophic dogs
,
Enteric nervous system
,
Ganglia
,
Gastrointestinal diseases
,
Gastrointestinal tract
,
Ileum
,
Ileum - metabolism
,
Ileum - pathology
,
immunohistochemistry
,
Intestinal motility
,
Intestine
,
Microscopy
,
Morphology
,
Muscular dystrophy
,
Muscular Dystrophy, Animal - metabolism
,
Muscular Dystrophy, Animal - pathology
,
Myenteric plexus
,
Myenteric Plexus - metabolism
,
Myenteric Plexus - pathology
,
Neurons
,
Neurons - metabolism
,
Neurons - pathology
,
Nitric oxide
,
Nitric Oxide Synthase - metabolism
,
Nitric-oxide synthase
,
Receptors, Purinergic P2X7 - metabolism
,
Transmission electron microscopy
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