Details

Autor(en) / Beteiligte

• Metzelder, S.K.
• Schroeder, T.
• Lübbert, M.
• Ditschkowski, M.
• Götze, K.
• Scholl, S.
• Meyer, R.G.
• Dreger, P.
• Basara, N.
• Fey, M.F.
• Salih, H.R.
• Finck, A.
• Pabst, T.
• Giagounidis, A.
• Kobbe, G.
• Wollmer, E.
• Finke, J.
• Neubauer, A.
• Burchert, A.

Titel

Long-term survival of sorafenib-treated FLT3-ITD–positive acute myeloid leukaemia patients relapsing after allogeneic stem cell transplantation

Ist Teil von

• European journal of cancer (1990), 2017-11, Vol.86, p.233-239

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD)–positive acute myeloid leukaemia (AML) relapsing after allogeneic stem cell transplantation (allo-SCT) has a dismal prognosis with limited therapeutic options. FLT3-ITD kinase inhibition is a reasonable but palliative experimental treatment alternative in this situation. Information on long-term outcome is not available. We performed a long-term follow-up analysis of a previously reported cohort of 29 FLT3-ITD–positive AML patients, which were treated in relapse after allo-SCT with sorafenib monotherapy. With a median follow-up of 7.5 years, 6 of 29 patients (21%) are still alive. Excluding one patient who received a second allo-SCT, five patients (17%) achieved sustained complete remissions with sorafenib. Four of these patients are in treatment-free remission for a median of 4.4 years. Sorafenib may enable cure of a proportion of very poor risk FLT3-ITD–positive AML relapsing after allo-SCT. •Sorafenib induces long-term survival in Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD)+ acute myeloid leukaemia (AML) relapsing after allogeneic stem cell transplantation (allo-SCT).•Sorafenib cures a minority of FLT3-ITD+ AML relapsing after allo-SCT.•Achievement of molecular negativity is strongly associated with cure.