Details

Autor(en) / Beteiligte

• Petrini, Agnese
• Pettinari, Riccardo
• Marchetti, Fabio
• Pettinari, Claudio
• Therrien, Bruno
• Galindo, Agustı́n
• Scopelliti, Rosario
• Riedel, Tina
• Dyson, Paul J

Titel

Cytotoxic Half-Sandwich Rh(III) and Ir(III) β‑Diketonates

Ist Teil von

• Inorganic chemistry, 2017-11, Vol.56 (21), p.13600-13612

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A series of half-sandwich pentamethylcyclopentadienyl rhodium­(III) and iridium­(III) complexes [Cp*M­(DBM/HDB/AVB)­Cl] and [Cp*M­(DBM/HDB/AVB)­(PTA)]­[SO3CF3], where Cp* = pentamethylcyclopentadienyl, the proligands DBMH = dibenzoylmethane, HDBH = o-hydroxydibenzoylmethane, AVBH = avobenzone, and PTA = 1,3,5-triaza-7-phosphaadamantane, is reported. All the complexes were characterized by IR, 1H and 13C NMR spectroscopy, electrospray ionization mass spectrometry, elemental analysis, and DFT calculations. Five of the complexes have also been characterized in the solid-state by X-ray crystallography. The cytotoxicity of the complexes has been evaluated against human ovarian A2780 and A2780cisR cell lines and, with the only exception of complexes 1 and 2 that display a negligible cytotoxicity, exhibit moderate cytotoxicity toward both cancer cell lines. However, the complexes do not show cancer cell selectivity with respect to human embryonic kidney HEK293 cells.