Details

Autor(en) / Beteiligte

• Clegg, Daniel O
• Reda, Domenic J
• Harris, Crystal L
• Klein, Marguerite A
• O'Dell, James R
• Hooper, Michele M
• Bradley, John D
• Bingham, Clifton O
• Weisman, Michael H
• Jackson, Christopher G
• Lane, Nancy E
• Cush, John J
• Moreland, Larry W
• Schumacher, H. Ralph
• Oddis, Chester V
• Wolfe, Frederick
• Molitor, Jerry A
• Yocum, David E
• Schnitzer, Thomas J
• Furst, Daniel E
• Sawitzke, Allen D
• Shi, Helen
• Brandt, Kenneth D
• Moskowitz, Roland W
• Williams, H. James

Titel

Glucosamine, Chondroitin Sulfate, and the Two in Combination for Painful Knee Osteoarthritis

Ist Teil von

• The New England journal of medicine, 2006-02, Vol.354 (8), p.795-808

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

2006

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• In this 24-week trial, glucosamine and chondroitin sulfate were not more effective, alone or in combination, than placebo in controlling pain in patients with osteoarthritis of the knee. In secondary analyses, however, in the subgroup of patients with moderate-to-severe osteoarthritis, those given both glucosamine and chondroitin sulfate were more likely than those given placebo to have a decrease in pain (79 percent vs. 54 percent). In this trial, glucosamine and chondroitin sulfate were not more effective, alone or in combination, than placebo in controlling pain in patients with osteoarthritis of the knee. Osteoarthritis is the most common of the arthritides, affecting at least 20 million Americans, a number that is expected to double over the next two decades. 1 , 2 Currently available medical therapies primarily address the treatment of joint pain in patients with osteoarthritis. 3 Analgesics as well as traditional and cyclooxygenase-2–selective nonsteroidal antiinflammatory drugs (NSAIDs) have suboptimal effectiveness, 4 , 5 and there is some question about their safety, especially in the light of recent reports of increased cardiovascular risk. 6 – 8 The dietary supplements glucosamine and chondroitin sulfate have been advocated, especially in the lay media, as safe and effective options for the management . . .