Leukemia research, 2007-08, Vol.31 (8), p.1135-1139
2007
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Details
- Autor(en) / Beteiligte
- Titel
- Erythroleukaemia, diabetes insipidus and hypophyseal damage: Two case reports
- Ist Teil von
- Leukemia research, 2007-08, Vol.31 (8), p.1135-1139
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2007
- Quelle
- ScienceDirect
- Beschreibungen/Notizen
- Abstract We report on two cases of patients who developed diabetes insipidus (DI) before acute erythroleukaemia (EL). A brain MRI showed an empty sella turcica in one case and hypothalamo-hypophyseal peduncle damage in the second case. Reduced levels of TGF-β1 and Vitamin D3, with associated EVI-1 over-expression and karyotypic abnormalities were documented. These two cases show specific chromosomal/molecular alterations in EL with DI. The hypothesis of pituitary involvement in erythroleukemogenesis is discussed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0145-2126eISSN: 1873-5835DOI: 10.1016/j.leukres.2006.11.008Titel-ID: cdi_proquest_miscellaneous_19521135
- Format
- –
- Schlagworte
- Adult, Cholecalciferol - blood, Chromosome Aberrations, Diabetes insipidus, Diabetes Insipidus - complications, Diabetes Insipidus - diagnosis, Diabetes Insipidus - metabolism, DNA-Binding Proteins - genetics, DNA-Binding Proteins - metabolism, Empty sella, Empty Sella Syndrome - chemically induced, Empty Sella Syndrome - diagnosis, Empty Sella Syndrome - metabolism, Erythroleukaemia, EVI-1, Female, Hematology, Oncology and Palliative Medicine, Humans, Hypothalamic Diseases - complications, Hypothalamic Diseases - diagnosis, Hypothalamic Diseases - metabolism, Leukemia, Erythroblastic, Acute - complications, Leukemia, Erythroblastic, Acute - diagnosis, Leukemia, Erythroblastic, Acute - metabolism, Magnetic Resonance Imaging, Male, MDS1 and EVI1 Complex Locus Protein, Middle Aged, Pituitary Gland - pathology, Proto-Oncogenes - genetics, TGF-β1, Transcription Factors - genetics, Transcription Factors - metabolism, Transforming Growth Factor beta1 - metabolism