Details

Autor(en) / Beteiligte

• Soofiyani, Saiedeh Razi
• Hejazi, Mohammad Saeid
• Baradaran, Behzad

Titel

The role of CIP2A in cancer: A review and update

Ist Teil von

• Biomedicine & pharmacotherapy, 2017-12, Vol.96, p.626-633

Ort / Verlag

France: Elsevier Masson SAS

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Abstract Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a characterized human oncoprotein that is able to promote cancer cells proliferation, anchorage-independent cell growth and resistance to apoptosis. CIP2A inactivates protein phosphatase 2A (PP2A) which down-regulates Akt (Protein Kinase B) phosphorylation and stabilizes c-Myc (c-Myc oncogene product) in cancer cells. CIP2A has been studied in the most of human malignancies. Here we discuss the role of CIP2A in cancer and give a summary of CIP2A expression in malignancies. Also, where available we indicated the association of CIP2A with the stage of cancers and patients prognosis, explain its localization and the possibility of targeting CIP2A in different cancers.