Details

Autor(en) / Beteiligte

• Boerwinkle, Varina L.
• Vedantam, Aditya
• Lam, Sandi
• Wilfong, Angus A.
• Curry, Daniel J.

Titel

Connectivity changes after laser ablation: Resting-state fMRI

Ist Teil von

• Epilepsy research, 2018-05, Vol.142, p.156-160

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• •RsfMRI detects changes in functional connectivity after laser ablation for epilepsy.•RsfMRI complements conventional MRI in evaluating seizure recurrence after surgery.•RsfMRI could potentially be used as a noninvasive imaging biomarker in epilepsy. Resting-state functional magnetic resonance imaging (rsfMRI) is emerging as a useful tool in the multimodal assessment of patients with epilepsy. In pediatric patients who cannot perform task-based fMRI, rsfMRI may present an adjunct and alternative. Although changes in brain activation during task-based fMRI have been described after surgery for epilepsy, there is limited data on the role of postoperative rsfMRI. In this short review, we discuss the role of postoperative rsfMRI after laser ablation of seizure foci. By establishing standardized anesthesia protocols and imaging parameters, we have been able to perform serial rsfMRI at postoperative follow-up. The development of in-house software that can merge rsfMRI images to surgical navigation systems has allowed us to enhance the clinical applications of this technique. Resting-state fMRI after laser ablation has the potential to identify changes in connectivity, localize new seizure foci, and guide antiepileptic therapy. In our experience, rsfMRI complements conventional MR imaging and task-based fMRI for the evaluation of patients with seizure recurrence after laser ablation, and represents a potential noninvasive biomarker for functional connectivity.