Details

Autor(en) / Beteiligte

• Millán, M.
• Grau, L.
• Castellanos, M.
• Rodríguez-Yáñez, M.
• Arenillas, J. F.
• Nombela, F.
• Pérez de la Ossa, N.
• López-Manzanares, L.
• Serena, J.
• Castillo, J.
• Dávalos, A.

Titel

Body temperature and response to thrombolytic therapy in acute ischaemic stroke

Ist Teil von

• European journal of neurology, 2008-12, Vol.15 (12), p.1384-1389

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective:  To determine the relationship between body temperature (BT), arterial recanalization, functional outcome, and hemorrhagic transformation (HT) of cerebral infarction in patients treated with i.v. tissue plasminogen activator (tPA). Methods:  We studied 254 patients treated with tPA within 3 h from stroke onset. National Institute of Health Stroke Scale score, BT, and transcranial Doppler ultrasound (n = 99) on admission and at 24 h were recorded. Hypodensity volume and HT were evaluated on CT at 24–36 h. Poor outcome (Rankin Scale > 2) was evaluated at 3 months. Results:  Arterial recanalization at 24 h was found in 70.7% of patients, HT in 24.8% (symptomatic in 4.7%) and poor outcome in 44.1%. Baseline BT was not associated with greater stroke severity at admission or at 24 h, HT or poor outcome. However, BT at 24 h correlated to stroke severity (P < 0.001) and hypodensity volume (P < 0.001) at 24 h, and was higher in patients who did not recanalize (P = 0.001), had symptomatic HT (P = 0.063) and poor outcome (P < 0.001). The adjusted odds ratio of poor outcome for patients with BT at 24 h ≥ 37°C was 2.56 (1.19–5.50, P = 0.016). Conclusion:  Body temperature ≥37°C at 24 h, but not at baseline, is associated with a lack of recanalization, greater hypodensity volume and worse outcome in stroke patients treated with tPA.