Details

Autor(en) / Beteiligte

• Kale, Sangeeta N
• Arora, Sumit
• Bhayani, Kavita R
• Paknikar, Kishore M
• Jani, Mona
• Wagh, Ulhas V
• Kulkarni, Shailaja D
• Ogale, Satish B

Titel

Cerium doping and stoichiometry control for biomedical use of La sub(0.7)Sr sub(0.3)MnO sub(3) nanoparticles: microwave absorption and cytotoxicity study

Ist Teil von

• Nanomedicine, 2006-12, Vol.2 (4), p.217-221

Erscheinungsjahr

2006

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• La sub(0.7)Sr sub(0.3)MnO sub(3) nanoparticles doped with cerium (La sub(0.7-x)Ce sub(x)Sr sub(0.3)MnO sub(3) where 0 <= x <= 0.7) as well as the La sub(1-y)Sr sub(y)MnO sub(3) nanoparticles with different values of y (La/Sr ratio) are evaluated for cytotoxicity and heating application. Considering hyperthermia as one of the possible application domains of such materials, the cytotoxicity studies were done on human skin carcinoma and human fibrosarcoma cell lines. All the samples showed the desired heating effect when subjected to high-frequency exposure at 2.45 GHz. Cytotoxicity studies revealed extremely low cytotoxicity in Ce-doped samples as well as in samples with a reduced La/Sr ratio. A maximum percentage cell viability on exposure to these nanoparticles was 95% and 85% for the two groups of samples, respectively, with a dose of 20 mu g/mL for the x = 0.4 sample. The issues of dopant solubility and nonstoichiometry are discussed.