Journal of experimental therapeutics & oncology, 2017-09, Vol.11 (2), p.139-416
2017
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- Autor(en) / Beteiligte
- Titel
- Effect of lupeol on antioxidants and xenobiotic enzymes in N-Butyl-N-(4-hydroxybutyl) nitrosamine induced bladder carcinogenesis in experimental rats
- Ist Teil von
- Journal of experimental therapeutics & oncology, 2017-09, Vol.11 (2), p.139-416
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Urothelial carcinoma of the bladder is a common malignancy ranked 9 with an estimated 356,600 new cases diagnosed annually worldwide. The study showed the protective effects of Lupeol in N-Butyl-N-(4-hydroxybutyl) nitrosamine induced bladder carcinogenesis in in vivo experimental model. Forty male healthy wistar rats were selected randomly divided into four groups. Group I rats served as healthy control. Group II rats were treated with BBN (150 mg/gavage/twice a week) for 8 weeks. Group III rats were treated with BBN + Lupeol [ Lupeol (50 mg/kg bw/day) treatment was started 1 week prior to the BBN treatment, and it was orally administered for 8 weeks]. Group IV rats were treated with Lupeol alone (50 mg/kg bw/day) for 8 weeks. All the experimental rats were maintained and euthanized at 32 week. Serum and bladder tissues were collected and examined for biochemical parameters, serum markers and histopathological evaluation. Preventive (BBN + Lupeol) group modulates the activity of antioxidant enzymes such as Superoxide dismutase, Catalase, Reduced glutathione, Glutathione Peroxidase, Thiobarbituric acid reactive substances (TBARS) and drug metabolizing enzymes such as Cytochrome P450, Cytochrome b5, NADPH Cytochrome c reductase, NADPH- Quinone Oxidoreductase 1 and Glutathione-S-transferase when compared to BBN treated rats. Serological markers such as Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) were significantly (P<0.05) decreased in preventive lupeol treated groups. Lupeol supplementation protects BBN induced bladder carcinogenesis in experimental rats by its antioxidant, anti-inflammatory and antiproliferative properties.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1359-4117Titel-ID: cdi_proquest_miscellaneous_1947098700
- Format
- –
- Schlagworte
- Animals, Anti-Inflammatory Agents - pharmacology, Antioxidants, Butylhydroxybutylnitrosamine - toxicity, Carcinogenesis - drug effects, Carcinoma, Transitional Cell - chemically induced, Carcinoma, Transitional Cell - enzymology, Carcinoma, Transitional Cell - metabolism, Carcinoma, Transitional Cell - pathology, Catalase - drug effects, Catalase - metabolism, Cytochrome P-450 Enzyme System - drug effects, Cytochrome P-450 Enzyme System - metabolism, Cytochromes b5 - drug effects, Cytochromes b5 - metabolism, Glutathione - drug effects, Glutathione - metabolism, Glutathione Peroxidase - drug effects, Glutathione Peroxidase - metabolism, Glutathione Transferase - drug effects, Glutathione Transferase - metabolism, Male, NAD(P)H Dehydrogenase (Quinone) - drug effects, NAD(P)H Dehydrogenase (Quinone) - metabolism, NADPH-Ferrihemoprotein Reductase - drug effects, NADPH-Ferrihemoprotein Reductase - metabolism, Pentacyclic Triterpenes - pharmacology, Rats, Rats, Wistar, Superoxide Dismutase - drug effects, Superoxide Dismutase - metabolism, Thiobarbituric Acid Reactive Substances - metabolism, Urinary Bladder - drug effects, Urinary Bladder - enzymology, Urinary Bladder - metabolism, Urinary Bladder - pathology, Urinary Bladder Neoplasms - chemically induced, Urinary Bladder Neoplasms - enzymology, Urinary Bladder Neoplasms - metabolism, Urinary Bladder Neoplasms - pathology