Details

Autor(en) / Beteiligte

• Kim, Y. G.
• Kim, H. W.
• Cho, Y. M.
• Oh, J. S.
• Nah, S.-S.
• Lee, C.-K.
• Yoo, B.

Titel

The difference between lupus nephritis class IV-G and IV-S in Koreans: focus on the response to cyclophosphamide induction treatment

Ist Teil von

• Rheumatology (Oxford, England), 2008-03, Vol.47 (3), p.311-314

Ort / Verlag

Oxford: Oxford University Press

Erscheinungsjahr

2008

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Objectives. To evaluate the response to induction therapy with intravenous (IV) cyclophosphamide (CYC) in Korean patients with class IV-G (diffuse global proliferative glomerulonephritis) and class IV-S (diffuse segmental proliferative glomerulonephritis) lupus nephritis (LN) according to the classification system of the International Society of Nephrology/Renal Pathology Society (ISN/RPS). Methods. Of the 52 patients with biopsy-proven diffuse proliferative LN, who had been treated with IV CYC over a 10-yr period, 42 had been treated with IV CYC (equal to or more than 500 mg) for 6 consecutive months and had biopsy specimens containing more than nine glomeruli. The renal pathology of these 42 patients was reclassified according to the International Society of Nephrology and the Renal Pathology Society 2003 classification, and their renal response rates and laboratory indices after induction therapy were analysed. Results. Of the 42 patients assessed, 30 (71%) had IV-G and 12 (29%) had IV-S. Pre-treatment 24 h urinary protein was significantly higher and pre-treatment concentration of anti-dsDNA antibody was significantly lower in IV-G than in IV-S patients. Following induction therapy, complete remission rates were significantly higher in patients with IV-S (67%, 8/12) than in patients with IV-G (33%, 10/30) LN. Conclusions. Class IV-G LN responded more poorly to induction therapy with IV CYC pulse than class IV-S LN.