Biological psychiatry (1969), 2006-12, Vol.60 (12), p.1314-1323
2006
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- Autor(en) / Beteiligte
- Titel
- Cognitive and Physical Activity Differently Modulate Disease Progression in the Amyloid Precursor Protein (APP)-23 Model of Alzheimer’s Disease
- Ist Teil von
- Biological psychiatry (1969), 2006-12, Vol.60 (12), p.1314-1323
- Ort / Verlag
- New York, NY: Elsevier Inc
- Erscheinungsjahr
- 2006
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- In aging mice, activity maintains hippocampal plasticity and adult hippocampal neurogenesis at a level corresponding to a younger age. Here we studied whether physical exercise and environmental enrichment would also affect brain plasticity in a mouse model of Alzheimer’s disease (AD). Amyloid precursor protein (APP)-23 mice were housed under standard or enriched conditions or in cages equipped with a running wheel. We assessed β-amyloid plaque load, adult hippocampal neurogenesis, spatial learning, and mRNA levels of trophic factors in the brain. Despite stable β-amyloid plaque load, enriched-living mice showed improved water maze performance, an up-regulation of hippocampal neurotrophin (NT-3) and brain-derived neurotrophic factor (BDNF) and increased hippocampal neurogenesis. In contrast, despite increased bodily fitness, wheel-running APP23 mice showed no change in spatial learning and no change in adult hippocampal neurogenesis but a down-regulation of hippocampal and cortical growth factors. We conclude that structural and molecular prerequisites for activity-dependent plasticity are preserved in mutant mice with an AD-like pathology. Our study might help explain benefits of activity for the aging brain but also demonstrates differences between physical and more cognitive activity. It also suggests a possible cellular correlate for the dissociation between structural and functional pathology often found in AD.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0006-3223eISSN: 1873-2402DOI: 10.1016/j.biopsych.2006.04.004Titel-ID: cdi_proquest_miscellaneous_19459250
- Format
- –
- Schlagworte
- Adult and adolescent clinical studies, Adult neurogenesis, Alzheimer Disease - chemically induced, Alzheimer Disease - pathology, Alzheimer Disease - psychology, Amyloid beta-Protein Precursor - toxicity, Animals, Biological and medical sciences, Brain - pathology, Brain-Derived Neurotrophic Factor - biosynthesis, Brain-Derived Neurotrophic Factor - genetics, Cell Count, Cerebral Cortex - metabolism, Cognition - physiology, Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases, Disease Progression, enriched environment, Environment, Female, Fibroblast Growth Factor 2 - biosynthesis, Hippocampus - metabolism, Insulin-Like Growth Factor I - biosynthesis, Maze Learning - physiology, Medical sciences, Mice, Mice, Transgenic, Motor Activity - physiology, mouse, Nerve Growth Factor - biosynthesis, Nerve Growth Factor - genetics, Neurology, neurotrophin, Neurotrophin 3 - biosynthesis, Neurotrophin 3 - genetics, Organic mental disorders. Neuropsychology, Psychology. Psychoanalysis. Psychiatry, Psychopathology. Psychiatry, Reverse Transcriptase Polymerase Chain Reaction, RNA, Messenger - biosynthesis, RNA, Messenger - genetics, stem cell, Vascular Endothelial Growth Factor A - biosynthesis, Vascular Endothelial Growth Factor A - genetics, water maze