Details

Autor(en) / Beteiligte

• Ha, Vanessa
• Viguiliouk, Effie
• Kendall, Cyril W.C.
• Balachandran, Bashyam
• Jenkins, David J.A.
• Kavsak, Peter A.
• Sievenpiper, John L.

Titel

Effect of a low glycemic index diet versus a high-cereal fibre diet on markers of subclinical cardiac injury in healthy individuals with type 2 diabetes mellitus: An exploratory analysis of a randomized dietary trial

Ist Teil von

• Clinical biochemistry, 2017-12, Vol.50 (18), p.1104-1109

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Markers of subclinical cardiac injury are elevated in individuals with type 2 diabetes mellitus (T2DM) compared to healthy individuals. Low glycemic index (LGI) diets may improve both diabetes and cardiovascular risk but their effects on cardiac injury and fibrosis have not been previously studied. To test the effect of a LGI diet on markers of subclinical cardiac injury and fibrosis, we assessed the effect of a LGI compared with a high-cereal fibre diet on high-sensitivity cardiac troponin I (hs-cTnI) and galectin-3 in otherwise healthy individuals with T2DM in an exploratory analysis of a completed randomized trial. A total of 201 participants completed the trial and had measurements of hs-cTnI and galectin-3 at baseline and at trial completion. Participants were randomized to follow a LGI or a high-cereal fibre diet over a 6-month period. Treatment differences were tested using Analysis of Covariance (ANCOVA) with sex, baseline values, and diet x sex interaction included as covariates. In a completer's analysis, no significant differences were observed for change in hs-cTnI (−0.16ng/L vs. −0.22ng/L, p=0.713) and galectin-3 levels (0.64μg/L vs. 0.14μg/L, p=0.166) when a LGI diet was compared to a high-cereal fibre diet. The effect of a LGI diet was similar to a high-cereal fibre diet on hs-cTnI and galectin-3 levels in otherwise healthy individuals with T2DM over a 6-month period. Nevertheless, in the absence of any adverse effects, LGI diets remain an option for diabetes and cardiovascular disease risk management. ClinicalTrials.gov identifier: NCT00438698 •Previous studies have shown that better glycemic control can lower subclinical cardiac injuries.•A low glycemic index (LGI) has been previously shown to improve glycemic control but its effects on subclinical cardiac injury has not been addressed before.•The effects of a LGI diet were similar to a high-cereal fibre diet on high-sensitivity cardiac troponin I and galectin-3.•A LGI diet is still warranted because previous studies have shown LGI to improve other cardiovascular risk factors.