Details

Autor(en) / Beteiligte

• Fiorentino, Teresa Vanessa
• Suraci, Evelina
• Arcidiacono, Gaetano Paride
• Cimellaro, Antonio
• Mignogna, Chiara
• Presta, Ivan
• Andreozzi, Francesco
• Hribal, Marta Letizia
• Perticone, Francesco
• Donato, Giuseppe
• Luzza, Francesco
• Sesti, Giorgio

Titel

Duodenal Sodium/Glucose Cotransporter 1 Expression Under Fasting Conditions Is Associated With Postload Hyperglycemia

Ist Teil von

• The journal of clinical endocrinology and metabolism, 2017-11, Vol.102 (11), p.3979-3989

Ort / Verlag

Washington, DC: Endocrine Society

Erscheinungsjahr

2017

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Context Type 2 diabetes (T2DM) is associated with a higher intestinal expression of the glucose transporters sodium/glucose cotransporter 1 (SGLT-1) and glucose transporter 2 (GLUT-2). It is currently unsettled whether prediabetes conditions characterized by postprandial hyperglycemia, such as impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) with 1-hour postload glucose ≥155 mg/dL (8.6 mmol/L) (NGT-1h-high) are associated with increased expression of these glucose carriers in the intestine. Objective We evaluated whether duodenal abundance of SGLT-1 and GLUT-2 is augmented in subjects with IGT and NGT-1h-high, in comparison with subjects with NGT and 1-hour postload glucose ˂155 mg/dL (NGT-1h-low). Design Cross-sectional. Patients A total of 54 individuals underwent an upper gastrointestinal endoscopy. Main Outcome Measures Duodenal SGLT-1 and GLUT-2 protein and messenger RNA levels were assessed by Western blot and reverse transcription polymerase chain reaction, respectively. Results Of the 54 subjects examined, 18 had NGT-1h-low, 12 had NGT-1h-high, 12 had IGT, and 12 had T2DM. Duodenal SGLT-1 protein and messenger RNA levels were significantly higher in individuals with NGT-1h-high, IGT, or T2DM in comparison with NGT-1h-low subjects. GLUT-2 abundance was higher in individuals with T2DM in comparison with NGT-1h-low subjects; no substantial increase in GLUT-2 expression was observed in NGT-1h-high or IGT individuals. Univariate correlations showed that duodenal SGLT-1 abundance was positively correlated with 1-hour postload plasma glucose levels (r = 0.44; P = 0.003) but not with fasting or 2-hour postload glucose levels. Conclusions Duodenal SGLT-1 expression is increased in individuals with 1-hour postload hyperglycemia or IGT, as well as in subjects with T2DM, and it positively correlates with early postload glucose excursion. We studied the duodenal expression of the glucose transporter SGLT-1 in individuals with dysglycemia and we found that duodenal SGLT-1 abundance is increased in subjects with post-load hyperglycemia.