Details

Autor(en) / Beteiligte

• Chakraborty, Apurba
• Rahman, Mahmudur
• Hossain, M. Jahangir
• Khan, Salah Uddin
• Haider, M. Sabbir
• Sultana, Rebeca
• Rimi, Nadia Ali
• Islam, M. Saiful
• Haider, Najmul
• Islam, Ausraful
• Shanta, Ireen Sultana
• Sultana, Tahmina
• Mamun, Abdullah Al
• Homaira, Nusrat
• Goswami, Doli
• Nahar, Kamrun
• Alamgir, A. S. M.
• Rahman, Mustafizur
• Jamil, Khondokar Mahbuba
• Azziz-Baumgartner, Eduardo
• Simpson, Natosha
• Shu, Bo
• Lindstrom, Stephen
• Gerloff, Nancy
• Davis, C. Todd
• Katz, Jaqueline M.
• Mikolon, Andrea
• Uyeki, Timothy M.
• Luby, Stephen P.
• Sturm-Ramirez, Katharine

Titel

Mild Respiratory Illness Among Young Children Caused by Highly Pathogenic Avian Influenza A (H5N1) Virus Infection in Dhaka, Bangladesh, 2011

Ist Teil von

• The Journal of infectious diseases, 2017-09, Vol.216 (suppl_4), p.S520-S528

Ort / Verlag

US: Oxford University Press

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Background In March 2011, a multidisciplinary team investigated 2 human cases of highly pathogenic avian influenza A(H5N1) virus infection, detected through population-based active surveillance for influenza in Bangladesh, to assess transmission and contain further spread. Methods We collected clinical and exposure history of the case patients and monitored persons coming within 1 m of a case patient during their infectious period. Nasopharyngeal wash specimens from case patients and contacts were tested with real-time reverse-transcription polymerase chain reaction, and virus culture and isolates were characterized. Serum samples were tested with microneutralization and hemagglutination inhibition assays. We tested poultry, wild bird, and environmental samples from case patient households and surrounding areas for influenza viruses. Results Two previously healthy case patients, aged 13 and 31 months, had influenzalike illness and fully recovered. They had contact with poultry 7 and 10 days before illness onset, respectively. None of their 57 contacts were subsequently ill. Clade 2.2.2.1 highly pathogenic avian influenza H5N1 viruses were isolated from the case patients and from chicken fecal samples collected at the live bird markets near the patients’ dwellings. Conclusion Identification of H5N1 cases through population-based surveillance suggests possible additional undetected cases throughout Bangladesh and highlights the importance of surveillance for mild respiratory illness among populations frequently exposed to infected poultry.