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Were all carbapenemases created equal? Treatment of NDM-producing extensively drug-resistant Enterobacteriaceae: a case report and literature review
Ist Teil von
Infection, 2018-02, Vol.46 (1), p.1-13
Ort / Verlag
Berlin/Heidelberg: Springer Berlin Heidelberg
Erscheinungsjahr
2018
Link zum Volltext
Quelle
SpringerLink
Beschreibungen/Notizen
Purpose
There is currently a paucity of published literature focused on the treatment of infections caused by NDM-producing organisms.
Methods
We describe a case of a bacteraemia caused by an extensively drug-resistant (XDR) New Delhi metallo-β-lactamase (NDM)-producing Serratia marcescens and review the treatment options for XDR NDM-producing
Enterobacteriaceae
.
Results
Infections caused by New Delhi beta-lactamase (NDM)-producing
Enterobacteriaceae
are becoming increasingly prevalent worldwide. The presence of the enzyme results in multidrug-resistant and extensively drug-resistant phenotypes which often pose a treatment challenge. Despite this challenge, case reports and series have demonstrated good clinical outcomes with numerous treatment options in comparison to infections due to KPC-producing
Enterobacteriaceae
.
Conclusions
Further good-quality research focused on the treatment of NDM-producing
Enterobacteriaceae
is warranted.