Details

Autor(en) / Beteiligte

• Perrin, Charles L

Titel

pH-Free Measurement of Relative Acidities, Including Isotope Effects

Ist Teil von

• Methods in enzymology, 2017, Vol.596, p.331-368

Ort / Verlag

United States

Erscheinungsjahr

2017

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• A powerful pH-free multicomponent NMR titration method can measure relative acidities, even of closely related compounds, with excellent accuracy. The history of the method is presented, along with details of its implementation and a comparison with earlier NMR titrations using a pH electrode. Many of its areas of applicability are described, especially equilibrium isotope effects. The advantages of the method, some practical considerations, and potential pitfalls are considered.