Details

Autor(en) / Beteiligte

• Sui, Xue
• Yan, Lan
• Jiang, Yuan-ying

Titel

The vaccines and antibodies associated with Als3p for treatment of Candida albicans infections

Ist Teil von

• Vaccine, 2017-10, Vol.35 (43), p.5786-5793

Ort / Verlag

Netherlands: Elsevier Ltd

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• •The fungal cell wall is critical for colonization and invasion of the host.•Als3p participates in adhesion, invasion, biofilm formation, and iron acquisition.•The abundance of Als3p on the hyphal surface makes it an attractive target.•The NDV-3 vaccine is being prepared for Phase 2 clinical trial.•The antibodies associated with Als3p have good protection by recognizing Als3p. Candida albicans is the most common fungal microorganism in healthy individuals, as well as the cause of high mortality infections in high-risk hosts such as immunocompromised patients. Antifungal vaccines and monoclonal antibodies useful for active or passive immunizations have recently generated considerable excitement for the treatment of fungal infections. The cell wall proteins of C. albicans, which are crucial for virulence and pathogenicity, are attractive target antigens. Als3p, a member of the C. albicans agglutinin-like sequence (ALS) family, is a hyphal-specific glycophosphatidylinositol cell wall protein that plays a key role in the interaction with host cells. The abundance of Als3p on the hyphal surface makes it an attractive target. For example, the NDV-3 vaccine, targeted at the N-terminus of Als3p, has entered a preparation of Phase 2 clinical trial. The Als3p-specific antibodies include monoclonal antibodies (MAbs) 3-A5, MAb 113, and scFv3. In addition, MAb C7, MAb 3D9.3 and MAb 2G8, which were supposed to be identifying other targets, have also provided good protection by recognizing Als3p. In this review, we summarize the functions of Als3p and highlight the development of the vaccines and the antibodies that are associated, directly or indirectly, with this protein.