Details

Autor(en) / Beteiligte

• Ekren, Pervin Korkmaz
• Ranzani, Otavio T
• Ceccato, Adrian
• Li Bassi, Gianluigi
• Muñoz Conejero, Eva
• Ferrer, Miquel
• Niederman, Michael S
• Torres, Antoni

Titel

Evaluation of the 2016 Infectious Diseases Society of America/American Thoracic Society Guideline Criteria for Risk of Multidrug-Resistant Pathogens in Patients with Hospital-acquired and Ventilator-associated Pneumonia in the ICU

Ist Teil von

• American journal of respiratory and critical care medicine, 2018-03, Vol.197 (6), p.826-830

Ort / Verlag

United States: American Thoracic Society

Erscheinungsjahr

2018

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Risk factors for multidrug-resistant (MDR) pathogens were defined on the basis of a systematic review, and local resistance MDR patterns were greatly emphasized.[...]we assessed the predictive performance of risk factors for MDR causing HAP/VAP in a single-center prospective cohort including six ICUs.In our single-center study, we found that nearly all the patients with HAP/VAP had at least one MDR risk factor, as defined in the 2016 IDSA/ATS guidelines.[...]the current risk factors for MDR pneumonia had high sensitivity, but low specificity, resulting in moderate NPV values and high NPV for MRSA and MDR Pseudomonas.[...]we evaluated the predictive performance of each risk factor, showing the high expected proportion of patients who would receive optimal empiric antibiotic coverage (only 3% undertreated).The level of evidence available for defining MDR risk factors in the current guidelines was of low quality, resulting in weak recommendations.[...]the definitions found to define an MDR pathogen were not consistent, where the term "potentially resistant microorganisms" (9, 10) was often used instead of MDR pathogens (2).