Details

Autor(en) / Beteiligte

• Akiyama, Masato
• Okada, Yukinori
• Kanai, Masahiro
• Takahashi, Atsushi
• Momozawa, Yukihide
• Ikeda, Masashi
• Iwata, Nakao
• Ikegawa, Shiro
• Hirata, Makoto
• Matsuda, Koichi
• Iwasaki, Motoki
• Yamaji, Taiki
• Sawada, Norie
• Hachiya, Tsuyoshi
• Tanno, Kozo
• Shimizu, Atsushi
• Hozawa, Atsushi
• Minegishi, Naoko
• Tsugane, Shoichiro
• Yamamoto, Masayuki
• Kubo, Michiaki
• Kamatani, Yoichiro

Titel

Genome-wide association study identifies 112 new loci for body mass index in the Japanese population

Ist Teil von

• Nature genetics, 2017-10, Vol.49 (10), p.1458-1467

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2017

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Obesity is a risk factor for a wide variety of health problems. In a genome-wide association study (GWAS) of body mass index (BMI) in Japanese people (n = 173,430), we found 85 loci significantly associated with obesity (P < 5.0 × 10 ), of which 51 were previously unknown. We conducted trans-ancestral meta-analyses by integrating these results with the results from a GWAS of Europeans and identified 61 additional new loci. In total, this study identifies 112 novel loci, doubling the number of previously known BMI-associated loci. By annotating associated variants with cell-type-specific regulatory marks, we found enrichment of variants in CD19 cells. We also found significant genetic correlations between BMI and lymphocyte count (P = 6.46 × 10 , r = 0.18) and between BMI and multiple complex diseases. These findings provide genetic evidence that lymphocytes are relevant to body weight regulation and offer insights into the pathogenesis of obesity.