Details

Autor(en) / Beteiligte

• Jiang, Jing Zhi
• Ye, Jing
• Jin, Guang Yu
• Piao, Hong Mei
• Cui, Hong
• Zheng, Ming Yu
• Yang, Jin Shi
• Che, Nan
• Choi, Yun Ho
• Li, Liang Chang
• Yan, Guang Hai

Titel

Asiaticoside Mitigates the Allergic Inflammation by Abrogating the Degranulation of Mast Cells

Ist Teil von

• Journal of agricultural and food chemistry, 2017-09, Vol.65 (37), p.8128-8135

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• The effects of asiaticoside (AS) on allergic responses mediated by mast cells were investigated. AS showed no obvious cytotoxicity on RPMCs (rat peritoneal mast cells). AS reduced the intracellular calcium in RPMCs and deprived the histamine release and degranulation. AS also decreased the generation of antigen-induced tumor necrosis factor α, interleukin (IL)-4, IL-8, and IL-1β in RBL-2H3 cells sensitized by IgE. The suppression of AS on pro-inflammatory cytokines was related with the activation of the intracellular FcεRI and the inhibition of the nuclear factor-κB signaling pathway. In addition, AS disabled the phosphorylation of antigen-induced Syk, Lyn, Gab2, and PLCγ1, thus suppressing the downstream Akt phosphorylation and MAPKs pathways. It also increased HO-1 and Nrf2 expression time dependently. In summary, we demonstrate that AS suppresses the allergic inflammation mediated by mast cells and this effect might be mediated by FcεRI-dependent signaling pathways.