Details

Autor(en) / Beteiligte

• Lee, Jae Bin
• Kang, Mi Eun
• Kim, Joohee
• Lee, Chang Young
• Kee, Jung-Min
• Myung, Kyungjae
• Park, Jang-Ung
• Hong, Sung You

Titel

Direct diversification of unmasked quinazolin-4(3H)-ones through orthogonal reactivity modulation

Ist Teil von

• Chemical communications (Cambridge, England), 2017, Vol.53 (75), p.10394-10397

Ort / Verlag

England

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Here we report a set of direct functionalization methods of unmasked 2-phenylquinazolin-4(3H)-ones, a privileged alkaloid core, without the installation/removal event of protecting groups or exogenous coordinating moieties. Divergent pathways were modulated with transition-metal catalysts by suppressing competitive reactivities, leading to N-arylation, annulative π-extension, or C-H fluorination.