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Identification of an argpyrimidine-modified protein in human red blood cells from schizophrenic patients: A possible biomarker for diseases involving carbonyl stress
Ist Teil von
Biochemical and biophysical research communications, 2017-11, Vol.493 (1), p.573-577
Ort / Verlag
United States: Elsevier Inc
Erscheinungsjahr
2017
Quelle
ScienceDirect
Beschreibungen/Notizen
Argpyrimidine (ARP) is an advanced glycation end product thought to be generated from a reaction between methylglyoxal and arginine residues in proteins. In this study, we observed marked accumulation of an approximately 56 kD protein, reactive to anti-ARP antibodies, in the red blood cells (RBCs) of some patients with refractory schizophrenia. This ARP-modified protein was purified from the blood of schizophrenic patients and identified as selenium binding protein 1 (SBP1) by LC-MS/MS. This is the first report of ARP-modified proteins accumulating in RBCs of patients with diseases involving carbonyl stress. We also observed high accumulation of ARP-modified SBP1 in the RBCs of patients with chronic kidney disease. Therefore, this modified protein may be a novel marker of carbonyl stress.
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•An argpyrimidine-modified protein was accumulated in erythrocyte from schizophrenic patients.•We identified the argpyrimidine-modified protein in erythrocyte as selenium binding protein 1.•The argpyrimidine-modified SBP1 is a possible marker of carbonyl stress-related diseases.•Metabolic error of methylglyoxal may be involved in onset of carbonyl stress-type schizophrenia.