Details

Autor(en) / Beteiligte

• Fukazawa, Ryuji
• Kobayashi, Tohru
• Mikami, Masashi
• Saji, Tsutomu
• Hamaoka, Kenji
• Kato, Hitoshi
• Suzuki, Hiroyuki
• Tsuda, Etsuko
• Ayusawa, Mamoru
• Miura, Masaru
• Ebata, Ryota
• Kobayashi, Tomio
• Yashiro, Mayumi
• Ogawa, Shunichi

Titel

Nationwide Survey of Patients With Giant Coronary Aneurysm Secondary to Kawasaki Disease 1999–2010 in Japan

Ist Teil von

• Circulation Journal, 2017/12/25, Vol.82(1), pp.239-246

Ort / Verlag

Japan: The Japanese Circulation Society

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Background:Giant coronary aneurysm is the most severe sequela in Kawasaki disease, occurring in approximately 0.2% of patients in Japan. Regression is rare, while myocardial infarction (MI) and sudden death are relatively common. Herein, we reviewed patients with giant coronary aneurysm in a 10-year period.Methods and Results:A nationwide questionnaire survey was conducted based on a national epidemiological database from 1999 to 2010. We identified 355 giant coronary aneurysm patients, of whom 209 were analyzed. The 5- and 10-year total cardiac event-free rates were 0.72 and 0.68, respectively. Twelve patients died, and MI was observed in 32 patients (18.1%). Five and 6 deaths were due to coronary rupture and MI, respectively. All ruptures occurred within 1 month of onset, while most MI occurred within 18 months. There was no death beyond 2 years. Aneurysm size was significantly related to the occurrence of MI in both the right and left coronary arteries. At the time of writing, 55% of patients had no exercise limitations. And including patients who cannot perform strenuous exercises, 81% of patients were leading ordinary lives.Conclusions:Severe cardiac events are likely to occur within 2 years from onset of Kawasaki disease, while no deaths occurred beyond this time. Hence, careful monitoring is needed especially for the first 2 years. Most patients with giant coronary aneurysms can lead ordinary lives with appropriate management.