Details

Autor(en) / Beteiligte

• Götze, Sebastian
• Herbst-Irmer, Regine
• Klapper, Martin
• Görls, Helmar
• Schneider, Kilian R. A
• Barnett, Robert
• Burks, Thomas
• Neu, Ursula
• Stallforth, Pierre

Titel

Structure, Biosynthesis, and Biological Activity of the Cyclic Lipopeptide Anikasin

Ist Teil von

• ACS chemical biology, 2017-10, Vol.12 (10), p.2498-2502

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• The class of cyclic lipopeptide natural products consists of compounds with a diverse range of bioactivities. In this study, we elucidated the structure of the cyclic lipopeptide anikasin using X-ray crystallography, analyzed its biosynthetic gene cluster, and investigated its natural role in the interaction between the producer strain Pseudomonas fluorescens HKI0770 and protozoal predators. These results led to the conclusion that anikasin has dual functionality enabling swarming motility and acting as a niche amoebicide, which effectively inhibits the social amoeba Polysphondylium violaceum and protects the producer strain from protozoal grazing.