Details

Autor(en) / Beteiligte

• Yan, Pixi
• Luo, Sai
• Lu, J Yuyang
• Shen, Xiaohua

Titel

Cis- and trans-acting lncRNAs in pluripotency and reprogramming

Ist Teil von

• Current opinion in genetics & development, 2017-10, Vol.46, p.170-178

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2017

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• •Cis- and trans-acting lncRNAs are involved in stem cell pluripotency and reprogramming.•lncRNA-mediated cis regulation of nearby transcription is a prevalent phenomenon in mammalian gene regulation.•lncRNAs provide an additional layer of complexity to the regulation of genes. Pervasive transcription in mammalian genomes produces thousands of long noncoding RNA (lncRNA) transcripts. Although they have been implicated in diverse biological processes, the functional relevance of most lncRNAs remains unknown. Recent studies reveal the prevalence of lncRNA-mediated cis regulation on nearby transcription. In this review, we summarize cis- and trans-acting lncRNAs involved in stem cell pluripotency and reprogramming, highlighting the role of regulatory lncRNAs in providing an additional layer of complexity to the regulation of genes that govern cell fate during development.