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Gallic acid-based indanone derivatives have been synthesised. Indanones
10,
11,
12 and
14 showed potent anticancer activity (IC
50
=
0.022–2.2
μM) against human cancer cell lines. The most active indanone against MCF-7, that is, hormone-dependent breast cancer cell line (
10, IC
50
=
2.2
μM) showed no toxicity to human erythrocytes even at higher concentrations (100
μg/ml, 258
μM). While, some of the indanones exhibited toxicity to erythrocytes at higher concentrations. Gallic acid-based indanones may further be optimised as better anticancer agents with low toxicity.
Gallic acid-based indanone derivatives have been synthesised. Some of the indanones showed very good anticancer activity in MTT assay. Compounds
10,
11,
12 and
14 possessed potent anticancer activity against various human cancer cell lines. The most potent indanone (
10, IC
50
=
2.2
μM), against MCF-7, that is, hormone-dependent breast cancer cell line, showed no toxicity to human erythrocytes even at higher concentrations (100
μg/ml, 258
μM). While, indanones
11,
12 and
14 showed toxicities to erythrocytes at higher concentrations.